Mechanism of activation for the sirtuin 6 protein deacylase
نویسندگان
چکیده
منابع مشابه
Mechanism-based sirtuin enzyme activation
Sirtuin enzymes are NAD-dependent protein deacylases that play a central role in the regulation of healthspan and lifespan in organisms ranging from yeast to mammals. There is intense interest in the activation of the seven mammalian sirtuins (SIRT1-7) in order to extend mammalian healthspan and lifespan. However, there is currently no understanding of how to design sirtuin-activating compounds...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2020
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)49896-6